Self-Assembly of Carbon Nanotubes Into Two-Dimensional Geometries Using DNA Origami Templates
- Self-Assembly of Carbon Nanotubes Into Two-Dimensional Geometries Using DNA Origami Templates
A central challenge in nanotechnology is the parallel fabrication of complex geometries for nanodevices. Here we report a general method for arranging single-walled carbon nanotubes in two dimensions using DNA origami-a technique in which a long single strand of DNA is folded into a predetermined shape. We synthesize rectangular origami templates ( approximately 75 nm x 95 nm) that display two lines of single-stranded DNA ‘hooks’ in a cross pattern with approximately 6 nm resolution. The perpendicular lines of hooks serve as sequence-specific binding sites for two types of nanotubes, each functionalized non-covalently with a distinct DNA linker molecule. The hook-binding domain of each linker is protected to ensure efficient hybridization. When origami templates and DNA-functionalized nanotubes are mixed, strand displacement-mediated deprotection and binding aligns the nanotubes into cross-junctions. Of several cross-junctions synthesized by this method, one demonstrated stable field-effect transistor-like behaviour. In such organizations of electronic components, DNA origami serves as a programmable nanobreadboard; thus, DNA origami may allow the rapid prototyping of complex nanotube-based structures.
DNA origami templated self-assembly of discrete length single wall carbon nanotubes.Org Biomol Chem. 2013 Jan 28;11(4):596-8. doi: 10.1039/c2ob26942b. Epub 2012 Dec 3.PMID: 23208726
Biotechnological mass production of DNA origami.Nature. 2017 Dec 6;552(7683):84-87. doi: 10.1038/nature24650.PMID: 29219963
DNA origami-based nanoribbons: assembly, length distribution, and twist.Nanotechnology. 2011 Jul 8;22(27):275301. doi: 10.1088/0957-4484/22/27/275301. Epub 2011 May 20.PMID: 21597145
DNA origami: the art of folding DNA.Angew Chem Int Ed Engl. 2012 Jan 2;51(1):58-66. doi: 10.1002/anie.201105846. Epub 2011 Dec 7.PMID: 22162047 Review.
DNA origami: fold, stick, and beyond.Nanoscale. 2010 Mar;2(3):310-22. doi: 10.1039/b9nr00246d. Epub 2009 Nov 24.PMID: 20644813 Review.