New Study: Effectiveness of 2 of 3 Vaccines Drops Below 50% After 6 Months | Facts Matter November 9, 2021 by mosesman Fig. 1. Time dependent vaccine effectiveness against SARS-CoV-2 infection as estimated from Cox proportional hazards models, adjusted for age, race, ethnicity, sex, and comorbidity score.Vaccine effectiveness presented as (1 – hazard ratio × 100) and 95% confidence intervals. Effectiveness for each month was estimated from contrasts using product terms for vaccination status by time to most recent RT-PCR assay.